Saturday , 28 November 2020

Blog Archives

CLINICAL OUTCOME OF PATIENTS WITH ACUTE SCROTAL PAIN AT A TERTIARY RURAL CENTRE IN MAHARASHTRA

Introduction: Acute scrotum is a common reason for emergency consultation. Early scrotal exploration is mandatory if torsion of the testis suspected clinically. Objectives: To study management and clinical outcome of patients admitted with acute scrotal condition. Methods: This was a prospective observational study involving 60 patients hospitalized for Acute scrotum at tertiary rural centre, from September 2014 to September 2016. …

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DEXMEDETOMIDINE PREMEDICATION WITH KETAMINE AND PROPOFOL DURING BURNS DEBRIDEMENT AND DRESSINGS

Background: Burn patients undergo frequent extensive burn debridement and painful dressing changes. Ketamine and Propofol are the most common anesthetic used along with Opioids and Benzodiazepines in burns dressings. Studies have shown that concomitant use of Dexmedetomidine with Propofol and Ketamine. Objectives: To study the effects of Dexmedetomidine as premedication with Ketamine and Propofol as sole anesthetic agents during burns …

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EFFECT OF LEAD ON MALE REPRODUCTION IN EXPERIMENTAL ANIMAL MODEL

Introduction: In early 1960’s, there is a first evidence of the toxic effects ionizing radiation on elevated oxygen levels in aerobes and proposed that oxygen toxicity is due to free radical formation. An alteration between oxidants and antioxidants in favour of the oxidants, potentially leading to damage is termed ‘oxidative stress’. Lead and cadmium do not have any detectable beneficial …

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PREPARATION AND EVALUATION OF TRANSNASAL MICROEMULSION OF VIGABATRIN

Introduction: The objective of this study was to develop novel transnasal microemulsion containing Vigabatrin for treatment of epilepsy. Method: Oleic acid was selected as oil while Tween 80 and ethanol were selected as surfactant and co-surfactant respectively based on solubility results. Optimized ratio of Tween 80 and Ethanol was selected after developing pseudoternary phase diagrams for different ratio and microemulsions …

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ANTI INFLAMMATORY EFFECT OF CIPROFLOXACIN, AZITHROMYCIN AND DICLOFENAC SODIUM ON CARRAGEENAN INDUCED HIND PAW EDEMA IN MICE

Background: Obviously, antibacterial agents are primarily directed against bacteria. However, because microorganisms can initiate an exaggerated inflammatory reaction, and as pathogens which persist in cryptic reservoirs (cells or granuloma tissue) can be the underlying cause of chronic inflammation, the hypothesis that antibacterials can down regulate inflammation. Methodology: Healthy adult mice weighing 20 – 30 g and aged 6-8 weeks, each …

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SERUM PROLACTIN LEVELS IN TYPE-II DIABETES MELLITUS WITH RETINOPATHY PATIENTS IN AND AROUND HYDERABAD

Background & Objectives: Diabetes is a disease of metabolic dysregulation. Hyperglycemia and oxidative stress play a role in the development of late diabetic complications. Increased retinal vasopermeability occurs early in diabetes and is crucial for the development of sight-threatening diabetic retinopathy. Serum prolactin is proteolytically processed to vasoinhibins that inhibit the excessive retinal vasopermeability related to diabetic retinopathy. The aim …

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PRE-ANALYTICAL VARIABLES IN CLINICAL CHEMISTRY: TRAINING MEDICAL UNDERGRADUATES THROUGH CASE BASED DISCUSSION

Background: Pre-analytical variables in clinical chemistry are factors prior to the biochemical analysis of samples affecting laboratory test results accounting for 32-75% of errors leading to misdiagnosis, decreased quality of medical care services and wastage of monetary resources. Aim: To educate first year medical undergraduates about pre-analytical variables through case based discussion and lecture method of teaching and assess the …

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DETECTION OF JAPANESE ENCEPHALITIS VIRUS AND HERPES SIMPLEX VIRUS IN AES CASES BY ELISA AND PCR IN A TERTIARY CARE HOSPITAL OF EASTERN INDIA

Encephalitis is defined as inflammation of the brain parenchyma associated with neurologic dysfunction. AES occurs in explosive epidemics or in a non-epidemic (sporadic) form. Epidemic in India have been attributed to Japanese encephalitis virus (JEV) infection. Herpes simplex virus (HSV) is responsible for most sporadic cases of AES. This study was undertaken to detect JEV and HSV from CSF samples. …

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ANTI CONVULSANT EFFECT OF NIFEDIPINE, DIAZEPAM AND IN COMBINATION ON MES INDUCED EPILEPSY IN RATS

Background: The role of calcium in the process of epileptogenesis and neurotoxicity and excitotoxicity during status epilepticus is involved. In fact, epileptiform bursts are often associated with influx of calcium ion into the nerve cells and a decrease in the extracellular concentration of calcium precedes the onset of seizures. Aim: To investigate the activity of nifedipine, the dihydropyridine calcium channel …

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