Document
Metadata
Title
ORAL PEMPHIGUS - A CASE REPORT
Authors
Indupuru, Kundana
Description
PEMPHIGUS is a serious chronic skin disease characterized by the appearance of vesicles & bullae, small or large fluid filled blisters that develop in cycles. The term pemphigus refers to a group of autoimmune blistering diseases of skin and mucous membranes that are characterized histologically by intraepidermal blisters due to acantholysis and immunopathologically by an in vivo bound & circulating IgG directed against the cell surface of keratinocytes. Pemphigus vulgaris is the most common form and frequently affects oral cavity. Main antigen is Dsg 3 (desmoglein) but 50% of patients also have autoantibodies to Dsg 1. Dsg 3: Dsg 1 is directly proportional to severity. We present a case of pemphigus occurring in the oral cavity of a 45-year-old male. Treatment with oral prednisolone and topical steroid resulted in remission of the disease. Clinical features, histological features and treatment of pemphigus vulgaris will be discussed.
KEYWORDS: Pemphigus; Blisters; Acantholysis; Autoantibodies.
Source
International Journal of Clinical and Biomedical Research; Volume 1, Issue 4; October 2015; 62-65
Publisher
Sumathi Publications
Rights
Copyright (c) 2015 Kundana Indupuru, Keerthana K L, Ram Kumar Tirandas, K Sowjanya, C Mounija
Type
info:eu-repo/semantics/article
Date
2015-10-28
Format
application/pdf
Language
eng