Document
Metadata
Title
Gastric Ulcer: An overview
Authors
Hamid Khan, Aslam
Description
Gastric ulcers are breaks in the mucosa of the stomach lining that penetrate through the muscularis mucosa and extend more than 5 mm in diameter. When alterations occur to the defense mechanisms of the stomach, it can cause changes in the gastric mucosa, eventually resulting in erosion and then ulceration. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two major factors disrupting mucosal resistance to injury. Gastric ulcers are characterized by discontinuation in the inner lining of the gastrointestinal (GI) tract because of gastric acid secretion or pepsin. It extends into the muscularis propria layer of the gastric epithelium. It usually occurs in the stomach and proximal duodenum. It may involve the lower esophagus, distal duodenum, or jejunum. Epigastric pain usually occurs within 15–30 minutes following a meal in patients with a gastric ulcer. Conversely, the pain with a duodenal ulcer tends to occur 2–3 hours after a meal. The treatments for gastric ulcers, such as proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, have demonstrated adverse effects, relapses, and various drug interactions. On the other hand, medicinal plants and their chemical compounds are useful in preventing and treating numerous diseases.
Keywords: gastric ulcer, NSAIDs, epigastric pain, pathophysiology
Date
2023-04-11
Format
application/pdf
Language
eng
Publisher
Sumathi Publications
Rights
Copyright (c) 2023 Aslam Hamid Khan, MOHD ALTAF DAR, Mashooq Ahmad Mir
Source
International Journal of Current Research in Physiology and Pharmacology; Volume 7, Issue 3; 2023; 1-7
Subject
Gastric ulcer, NSAIDs, Epigastric Pain, Pathophysiology
Type
info:eu-repo/semantics/article