Effect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin

Journal: International Journal of Current Research in Physiology and Pharmacology

Article type: Research Article

Published: 2021-03-25

Volume: 5; Issue: 1; Pages: 1-10

ISSN: 2456-3891

DOI: 10.31878/ijcrpp.2021.51.02

Article URL: https://journals.sumathipublications.com/article/article-1782845628754-546692227

PDF: https://journals.sumathipublications.com/article/article-1782845628754-546692227.pdf

JATS XML: https://journals.sumathipublications.com/article/article-1782845628754-546692227.xml

Authors

  1. ahmed mohmed taha
    Department of physiology, faculty of medicine Port Said University,
  2. Haredy Hassan Haredy
    Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
  3. Ahmed Ghareip
    Department of Physiology, Faculty of Medicine, Al-Azhar University, Assuit, Egypt.
  4. Ahmed El sayed Nour el-deen
    Lecturer (Physiology Department, Faculty of Medicine, Al-Azhar University, EGYPT
  5. Yasser M Ashour
    Department of Physiology, Egyptian Russian University

Abstract

Diabetes Miletus (DM) is a global epidemic disease. It is estimated that there are already 415 million adults aged 20–79 years diabetics worldwide. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) and metformin (MET) is a biguanide used for the treatment of type 2 diabetes which increases peripheral insulin sensitivity. Aim : This study aims to assess the effect of sildenafil citrate and metformin on lipid profile and glycemic control in diabetic and prediabetic albino rats. Materials and methods : Adult male albino rats are used and divided into nine groups each group consists of 10 rats, diabetes is induced by feeding a high-fat diet (HFD) for an initial period of 2 weeks followed by a single intraperitoneal injection of (35 mg/kg) Streptozotocin. Prediabetes is induced by feeding (HFD) and glucose in water for a period of 2 weeks. Sildenafil was given in a dose of (5 &10 mg/kg/day orally for 4 weeks), metformin was given in a dose of (50 &100 mg/kg/day orally for 4 weeks) using oral gavages to normal healthy rats, diabetic and prediabetic rats. Blood samples were collected after 4 weeks of treatment in all experimental groups. Results : Combined administration of sildenafil and metformin on diabetic rats improving hyperglycemia, oxidative stress, and hyperlipidemia induced by streptozotocin than the administration of metformin or sildenafil alone. Conclusion : Sildenafil has beneficial effects against some diabetic complications. The present study showed that sildenafil with metformin has beneficial effects against diabetic complications.

Keywords

Diabetes Mellitus; DM; Sildenafil; Metformin

Full Text

HTML full text is not available. Refer to the PDF galley.