Hepatoprotective effect of aqueous extracts of Annona senegalensis (Annonaceae) and Hallea ledermannii (Rubiaceae) in alloxan-induced diabetic Wistar rat.

Authors

1. Gooré Guy Charles Golé Nanti
   Jean Lorougnon Guédé University, UFR Agroforestry, Agrovalorization Laboratory, BP 150 Daloa, Ivory Coast
2. Dosso Kassim
   Jean Lorougnon Guédé University, UFR Agroforestry, Biodiversity and Tropical Ecology Laboratory, BP 150 Daloa, Ivory Coast
3. Dago Désiré Koudou
   Jean Lorougnon Guédé University, UFR Agroforestry, Agrovalorization Laboratory, BP 150 Daloa, Ivory Coast
4. Bi Semi Anthelme Néné
   Félix Houphouët Boigny University, UFR Biosciences, Biology and Health Laboratory, 22 BP 582 Abidjan 22, Ivory Coast
5. Flavien Traoré
   Félix Houphouët Boigny University, UFR Biosciences, Biology and Health Laboratory, 22 BP 582 Abidjan 22, Ivory Coast

Abstract

ABSTRACT Context : Given the high cost of treating diabetics with modern medicine in developing countries like Africa, traditional medicine has become an alternative widely practiced by them for their care. Hence the need to carry out a preclinical test in order to make improved traditional medicines available to diabetics in these countries at lower cost. It is in this context that we undertook to carry out scientific studies that could also promote traditional African medicine. General objective : To evaluate the hepatoprotective effects of aqueous extracts of Annona senegalensis (Annonaceae) (EAAs) and Hallea ledermannii (Rubiaceae) (EAHl), two plants known to be antidiabetic, in diabetic rats of the Wistar strain. Material and methods : The study of the effects of EAAs and EAHl on lipid profile parameters and markers of liver function in non-diabetic rats and in those made diabetic by induction of alloxan at a single dose of 75 mg/ kg of body weight (bw) was carried out after two (2), four (4), eight (8) and thirteen (13) weeks of treatment. Also, the study of the influence of the effects of these aqueous extracts on the liver of these animals was carried out after four (4) and thirteen (13) weeks of treatment. Furthermore, the histological analysis of the liver of the test rats was carried out after measuring the relative weight of this organ, on the 91st day of treatment. Results : After four (4) weeks of treatment, only the value of LDL cholesterol (LDL-c) in rats treated with EAAs (200 mg/kg bw) significantly decreased (p < 0.05) compared to that of controls. untreated diabetics (1.27 ± 0.02 versus 1.18 ± 0.03 g/L). After 91 days of treatment, a significant increase in alkaline phosphatase and protein content was observed in diabetic rats treated with EAHl200 compared to the mean values ​​in untreated diabetic control rats respectively (137.5 ± 2. 50 against diabetic control values ​​93.50 ± 2.50) and (80 ± 3 g/L against diabetic control values ​​64 ± 4 g/L). At the same stage of treatment, the relative weight of the liver of all animals did not undergo significant variations (p > 0.05) compared to that of non-diabetic controls. Conclusion : This study highlighted the hepato-protective properties of these extracts in diabetics. Keywords : Annona Senegalensis , Hallea ledermannii, glibenclamide, hepato-protective, rat- diabetes.

Keywords

Annona Senegalensis; Hallea ledermannii; glibenclamide; hepato-protective; rat- diabetes

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