EFFECT OF NICORANDIL ON PENTYLENETETRAZOLE (PTZ) INDUCED CONVULSIONS IN MICE
Journal: International Journal of Clinical and Biomedical Research
Article type: Original Research Articles
Published: 2015-04-15
Volume: 1; Issue: 2; Pages: 99-101
ISSN: 2395-0471
Article URL: https://journals.sumathipublications.com/article/article-1784643709379-581680276
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Authors
- T Nageshwara Rao
Not available, refer to PDF - Bharatha Ambadasu
Not available, refer to PDF - S Vijay Prasad
Not available, refer to PDF - A Srinivas
Not available, refer to PDF - V Yakaiah
Not available, refer to PDF
Abstract
Aims & Objectives: To evaluate or screen the anticonvulsant effect of Nicorandil a potassium channel opener in Pentylenetetrazole(PTZ) induced convusions in albino mice. Materials & Methods: Mice of either sex weighing 20-25gms were selected for the present study. The animals were divided into 6 groups with each group consisting of 6 albino mice. Group 1 mice received placebo (0.2ml of distilled water) intraperitoneally (i.p), group 2 received sodium valproate 200 mg/kg/i.p. as positive control, while groups 3,4, 5 and 6 were administered Nicorandil 5, 10, 20 and 40 mg/kg i.p respectively. Pentylenetetrazole (PTZ) was administered in the dose of 100mg/kg i.p, 30mins after Nicorandil/ control drug pre-treatment. Onset and duration of clonic convulsion were recorded. Results: Nicorandil pretreatment in the dose of 5mg/kg increased onset time and significantly decreased the duration of convulsions,while the doses of 10, 20, 40mg/kg prevented the convulsions. Conclusion: Nicorandil possesses significant anticonvulsant activity comparable to sodium valproate on PTZ induced seizure in albino mice. KEYWORDS: Pentylenetetrazole; Sodium valproate; Nicorandil; Anticonvulsant activity.
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