ASSOCIATION BETWEEN MICROALBUMINURIA AND OXIDATIVE STRESS IN DIABETIC NEPHROPATHY
Journal: International Journal of Clinical and Biomedical Research
Article type: Original Research Articles
Published: 2015-04-15
Volume: 1; Issue: 2; Pages: 96-98
ISSN: 2395-0471
Article URL: https://journals.sumathipublications.com/article/article-1784643709382-653862340
PDF: https://journals.sumathipublications.com/article/article-1784643709382-653862340.pdf
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Authors
- P Prabhakar Rao
Not available, refer to PDF - C Sujatha
Not available, refer to PDF - N Madhavi Latha
Not available, refer to PDF - J Praveen Kumar
Not available, refer to PDF - M Deepa
Not available, refer to PDF
Abstract
Objectives: Diabetic Nephropathy (DN) is a leading cause of chronic kidney disease and end stage renal failure worldwide. This study aimed to evaluate the association between oxidants, antioxidants and microalbuminuria in Diabetic Nephropathy compared with Type II Diabetes Mellitus (DM). Methods: The study includes 60 Type II Diabetes Mellitus and 40 Diabetic Nephropathy Patients. Parameters performed HbA1c, urea, creatinine, total proteins, microalbuminuria, glutathione peroxidase and malondialdehyde(MDA). Results: The levels of HbA1c, urea, creatinine, microalbuminuria and malondialdehyde are significantly higher in DN compared with Type II DM. the levels of T.P and glutathione peroxidase are decreased in DN compared with Type II DM. Conclusion: Low levels of glutathione peroxidase and total proteins were observed in DN. HbA1c, urea, creatinine, microalbuminuria and malondialdehyde levels were elevated in DN compared with Type II DM. KEYWORDS: Diabetic Nephropathy; Glutathione peroxidase; Microalbuminuria; Malondialdehyde.
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