ORAL PEMPHIGUS - A CASE REPORT

Journal: International Journal of Clinical and Biomedical Research

Article type: Case Reports

Published: 2015-10-28

Volume: 1; Issue: 4; Pages: 62-65

ISSN: 2395-0471

Article URL: https://journals.sumathipublications.com/article/article-1784649756995-726411047

PDF: https://journals.sumathipublications.com/article/article-1784649756995-726411047.pdf

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Authors

  1. Kundana Indupuru
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  2. Keerthana K L
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  3. Ram Kumar Tirandas
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  4. K Sowjanya
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  5. C Mounija
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Abstract

PEMPHIGUS is a serious chronic skin disease characterized by the appearance of vesicles & bullae, small or large fluid filled blisters that develop in cycles. The term pemphigus refers to a group of autoimmune blistering diseases of skin and mucous membranes that are characterized histologically by intraepidermal blisters due to acantholysis and immunopathologically by an in vivo bound & circulating IgG directed against the cell surface of keratinocytes. Pemphigus vulgaris is the most common form and frequently affects oral cavity. Main antigen is Dsg 3 (desmoglein) but 50% of patients also have autoantibodies to Dsg 1. Dsg 3: Dsg 1 is directly proportional to severity. We present a case of pemphigus occurring in the oral cavity of a 45-year-old male. Treatment with oral prednisolone and topical steroid resulted in remission of the disease. Clinical features, histological features and treatment of pemphigus vulgaris will be discussed. 
 KEYWORDS:  Pemphigus; Blisters; Acantholysis; Autoantibodies.

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