RECURRENT PREGNANCY LOSS AND ASSOCIATION OF MTHFR, PAI-1 AND ACE GENE POLYMORPHISMS IN WOMEN

Journal: International Journal of Clinical and Biomedical Research

Article type: Review Articles

Published: 2015-10-28

Volume: 1; Issue: 4; Pages: 50-55

ISSN: 2395-0471

Article URL: https://journals.sumathipublications.com/article/article-1784649757002-633718328

PDF: https://journals.sumathipublications.com/article/article-1784649757002-633718328.pdf

JATS XML: https://journals.sumathipublications.com/article/article-1784649757002-633718328.xml

Authors

  1. Snehlata Pandey
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  2. Archana Pandey
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  3. U.K. Chauhan
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  4. Arvind Tripathi
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  5. Jitendra Tripathi
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  6. Sanjeev Dubey
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  7. Rishabh Deo Saket
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Abstract

Recurrent pregnancy loss (RPL) is a significant clinical problem that may occur before the 20 th  week of gestation. There is no general consensus on how many consecutive abortions are considered as RPL. The goal of this study is to investigate the correlation between recurrent miscarriage (RM) and common polymorphisms in angiotensin-converting enzyme  (ACE),  plasminogen activator inhibitor 1  (PAI-1)  and Methylenetetrahydrofolate Reductase (MTHFR) genes among women experiencing RM. The literature existing in different population was searched and based on these finding we conclude that polymorphism in either one of these genes may increase chances of miscarriage. 
 KEYWORDS:  Polymorphism; Recurrent pregnancy; Plasminogen activator inhibitor 1.

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