PREVENTIVE EFFECTS OF THE AQUEOUS EXTRACT OF CINNAMOMUM ZEYLANICUM BARK ON DEXAMETHASONE INDUCED INSULIN RESISTANCE IN WISTAR ALBINO RATS

Journal: International Journal of Clinical and Biomedical Research

Article type: Original Research Articles

Published: 2015-10-28

Volume: 1; Issue: 4; Pages: 14-20

ISSN: 2395-0471

Article URL: https://journals.sumathipublications.com/article/article-1784649757024-197603803

PDF: https://journals.sumathipublications.com/article/article-1784649757024-197603803.pdf

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Authors

  1. Rajasekhar CH
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  2. Nagendranayak IM
    Not available, refer to PDF
  3. Rajesh B
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  4. Kokila B Nagraju
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  5. Guruprasad N Banavasi
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  6. Hemanth Kumar V
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Abstract

Objectives:  To evaluate the preventive effects of aqueous extract of  Cinnamomum zeylanicum  bark on dexamethasone induced insulin resistance and to compare it with rosiglitazone.  Methods:  The animals were categorized into two series of dexamethasone (dexamethasone 4mg/kg, dexamethasone 8mg/kg series) with 5 groups in each [plain control, dexamethasone 4/8mg/kg as per series, rosiglitazone 8mg/kg and 16mg/kg,  cinnamon  bark extract (CZE) 250mg/kg BW]. Six animals were studied in each group. In a12 day study period, rosiglitazone and CZE groups received respective drug treatments and dexamethasone dosing (4mg/kg or 8mg/kg) was started from day 7onwards. On day 12, fasting blood, urine and post IPGTT blood samples were collected and processed for glucose, insulin and ketone estimations.  Results:  In both series, CZE 250mg/kg treatment showed significant reduction in mean fasting glucose and insulin compared to rosiglitazone 8mg/kg and 16mg/kg groups and dexamethasone controls (4mg/kg, 8mg/kg groups) ( P <0.05). The fall in glucose and insulin levels observed with CZE treatment at 30, 60 min post IPGTT in both series were significant compared to rosiglitazone and dexamethasone treatment groups ( P <0.05). Glycosuria and ketonuria were absent in CZE groups, whereas these were reduced significantly in rosiglitazone groups compared to dexamethasone groups ( P <0.05) . Conclusion:  The aqueous extract of  C. zeylanicum  bark prevented the insulin resistance as evidenced by reduced fasting and post IPGTT glucose and insulin levels in steroid induced insulin resistance model. 
 KEYWORDS:  Glucose uptake;   Cinnamon bark; Rosiglitazone; Hyperinsulinemia; Hyperglycemia.

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