STUDY OF LIPID PROFILE AND NON-HDL CHOLESTEROL AS A BIOMARKER OF CARDIOVASCULAR RISK IN TYPE 2 DIABETES MELLITUS

Authors

1. WARJUKAR PRAJAKTA R
   Department of Biochemistry, Indira Gandhi Govt. Medical College, Nagpur, India.
2. GHANGALE SS
   Department of Biochemistry, Indira Gandhi Govt. Medical College, Nagpur, India.
3. IYER CM
   Department of Biochemistry, Indira Gandhi Govt. Medical College, Nagpur, India.

Abstract

Introduction : The reduction of cardiovascular risk by lowering low-density lipoprotein cholesterol (LDL-C) is well documented, and LDL-C remains the main target of lipid lowering therapy. However, not all patients with cardiovascular risk have elevated LDL-C. There is growing recognition that non-high density lipoprotein cholesterol (Non-HDL-C) is strongly related to cardiovascular risk. Aim: This study was done to evaluate the importance of Non-HDL C in predicting cardiovascular risk in type 2 Diabetes Mellitus. Methods : 100 type 2 diabetic patients were taken as subjects. Fasting and post meal blood sugar, lipid profile, and Non-HDL C was analysed in these patients. The patients were divided in two groups depending on their Non- HDL C level; ≤130 mg/dl and > 130mg/dl. Result and discussion : In this study it was seen that, age <60 years, being female, BMI >25 kg/m 2 and LDL cholesterol >100mg/dl were associated with having Non-HDL cholesterol >130mg/dl. Conclusion : The results showed positive correlation between Non-HDL and LDL cholesterol. It also showed significant non achievement of Non-HDL cholesterol targets of ≤130mg/dl even if LDL cholesterol targets were achieved i.e. <100mg/dl suggesting the importance of measuring Non - HDL Cholesterol to predict the risk of cardiovascular disease in type 2 diabetes.

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