HEPARIN INDUCED THROMBOCYTOPENIA AND HEMODIALYSIS

Authors

1. AMAL S. ELHASSADE
   Not available, refer to PDF
2. AHLAM MOHAMED BEN NASER
   Not available, refer to PDF

Abstract

Unfractionated heparin is the most commonly used anticoagulant for hemodialysis (HD).  It is well-known that heparin can cause immune-mediated thrombocytopenia due to immunoglobulin antibody formation against the complex of platelet factor 4 (PF4) and heparin. Heparin may also contribute to HD-associated platelet activation, thrombocytopenia, and increased PF4 release from platelets during a heparin dialytic session. The present study was conducted to study the effect of unfraction heparin as anticoagulant in newly treatment hemodialysis patients.  Material and method : A sample of 72 people were selected, 32 patients on dialysis for first time from unite of kidney dialysis. At the same time a group of 40 randomly selected healthy adults to participate in the study as control. By Automated cell counter (sysmex X 21) platelets from all patients on dialysis before starting heparin and after one month later were estimated.  Result : The mean value of platelets in patients after treated with heparin was significant lower (192.3 ± 20.7 ) — 10 9 /l as compare before treated with heparin 203 ± 20.7 — 10 9 /l  ( P = 0.001).  Conclusion:  From this study, heparin as anti-coagulant has effect on decrease platelets count but still patients have no thrombocytopenia platelets level 150 — 10 9 /l.h

Full Text

HTML full text is not available. Refer to the PDF galley.