BACTERIOLOGICAL PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN IN INTENSIVE CARE UNIT OF TERTIARY CARE HOSPITAL, AURANGABAD.

Authors

1. Praful S. Patil
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2. Rangaiahagari Ashok
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Abstract

Introduction : Multidrug resistant nosocomial infections are one of the leading causes of morbidity and mortality in hospitalized patients especially the critically ill patients in the intensive care unit (ICU), where a large number of drugs are administered to the patient which in turn leads to the generation of antibiotic resistant pathogens.  Method : Over a period 12 months clinical samples (blood, urine, pus/ wound swabs, respiratory secretions etc) from patient admitted in ICU were processed according to the standard microbiologic methods, and their antimicrobial testing was performed using disk diffusion method.  Results : A total of 464 samples, 164 (35.34%) were culture positive in which 133 (81.1%) samples were monomicrobial and 31(63) (18.9%) samples were polymicrobial. Out of 196 isolates were obtained, 127 isolates were Gram negative and 69 isolates were Gram positive organisms. The most common isolate was  S. aureus  (29.1%) and  Klebsiella spp  (26%) followed by  E.coli  (17.3%),  Pseudomonas spp  (13.8%),  Streptococcus spp  (5.1%),  Acinetobacter spp  (4.1%),  Citrobacter  (2.6%), Proteus Spp (1%) and Coagulase Negative  Staphylococcus  (1%). Vancomycin and linazolid is more effect against the Gram positive organisms. For Gram negative organism's carbapenems remain the drug of choice followed by amikacin.  Conclusion : Institutional antimicrobial surveillance and proper infection control practices are essential to prevent and control multi drug resistant bugs in ICUs and hospital. 
 KEY WORDS:  Bacteriological profile; Antimicrobial profile; Intensive Care Unit infections; Nosocomial Infections.

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