Total body irradiation in a case of thalassemia major with source to axis distance based planning: A case report

Journal: International Journal of Clinical and Biomedical Research

Article type: Case Reports

Published: 2020-10-29

Volume: 6; Issue: 4; Pages: 25-28

ISSN: 2395-0471

DOI: 10.31878/ijcbr.2020.64.06

Article URL: https://journals.sumathipublications.com/article/article-1784653451975-246432542

PDF: https://journals.sumathipublications.com/article/article-1784653451975-246432542.pdf

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Authors

  1. Mayuresh D. Virkar
    Clinical Associates, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  2. Rajkumar Chauhan
    RSO, Medical Physicist, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  3. Pranav Chadha
    Head of the Unit, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  4. Kaustav Talapatra
    Head of the Department, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India
  5. Reuben Jake Rodrigues
    Medical Officer, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai.
  6. Amrita Shrivastava
    DMRT, Radiation Oncology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  7. Santanu Sen
    Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
  8. Sameer Tulpule
    Consultant, Haematology Dept., Kokilaben Dhirubhai Ambani Hospital, Mumbai, India

Abstract

Background: The use of total body radiation (TBI) before hematopoietic stem cell transplantation (HSCT) would increase the engraftment without transplant-related morbidity or mortality among Thalassemia major (TM) cases. Case presentation: A 2-year-old female child, diagnosed with TM was scheduled for haploidentical allogenic transplant-based protocol, and after that, based on protocol she was scheduled to undergo a single session of TBI as a conditioning regimen before haploidentical allogenic hematopoietic stem cell tranplant. A total dose of 4 Gy was administered.. The incidence of graft failure was reduced as TBI was used before allogeneic stem cell transplantation. TBI provided a uniform dose of radiation to the entire body, penetrating areas such as the central nervous system (CNS) and testes. Conclusion: Total Body Irradiation with the SAD technique is the most effective way of treatment. As it is comfortable for the patient to undergo, easily reproducible, and it helps to achieve a uniform dose distribution.

Keywords

Hematopoietic Stem Cell Transplantation; Graft-versus-Host Disease; Thalassemia Minor; Radiotherapy; Myeloablative conditioning; Haemoglobinopathies

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