ASSOCIATION OF SERUM COPEPTIN, CARDIAC TROPONIN T, AND ADIPONECTIN WITH ANGIOGRAPHIC SEVERITY OF CORONARY ARTERY DISEASE: A HOSPITAL-BASED CASE-CONTROL STUDY

Authors

1. Prangyada Reecha Joshi
   Associate Professor, Department of Biochemistry, DRIEMS Institute Of Health Sciences and Hospital, Tangi, Katak,Odisha, India
2. Pradosh Samal
   Assistant Professor, Department of Biochemistry, M.K.C.G Medical College and Hospital, Berhampur, Odisha, India
3. Banashree Swain
   Assistant Professor, Department of Biochemistry, S.C.B Medical College and Hospital, Katak, Odisha, India

Abstract

Background: Copeptin reflects activation of the arginine vasopressin stress axis, cardiac troponin T indicates myocardial injury, and adiponectin has anti-inflammatory and anti-atherogenic properties. Their combined relationship with angiographic coronary artery disease (CAD) severity remains incompletely characterized. Objective: To compare serum copeptin, cardiac troponin T, and adiponectin concentrations between patients with angiographically confirmed CAD and controls and to examine their relationship with angiographic disease severity. Methods: This hospital-based case-control study included 160 participants: 80 patients with angiographically confirmed CAD and 80 controls. Serum copeptin and adiponectin were measured by enzyme-linked immunosorbent assay, and cardiac troponin T was measured by chemiluminescence immunoassay. CAD severity was assessed using the Gensini score. Group comparisons, correlation analyses, and receiver operating characteristic (ROC) analyses were performed. Results: Among the CAD cases, 11 (13.75%) had mild, 24 (30.0%) moderate, and 45 (56.25%) severe disease. Mean serum copeptin (4.12 ± 2.23 vs 0.62 ± 0.036) and cardiac troponin T (3.36 ± 2.38 vs 0.022 ± 0.01) were higher in cases than controls, whereas adiponectin was lower (6.84 ± 2.16 vs 10.92 ± 3.48); the reported p value for each comparison was 0.001. Copeptin and troponin T showed positive associations with CAD severity, while adiponectin showed an inverse association. Reported AUC values were 0.703 for copeptin, 0.987 for troponin T, and 0.812 for adiponectin. Conclusion: Higher copeptin and cardiac troponin T concentrations and lower adiponectin concentrations were observed in patients with CAD and were associated with greater angiographic severity. Cardiac troponin T showed the strongest discrimination in this study sample. The findings should be interpreted in view of the baseline differences between cases and controls and the observational design.

Keywords

Adiponectin; Cardiac troponin T; Copeptin; Coronary artery disease; Gensini score.

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