Drug discovery and development is an intricate and multifaceted process that encompasses identifying, designing, and testing prospective new drugs. The primary objective is to discover secure and effective treatments for various ailments and conditions. This composition will delve into the various stages of drug design and screening and the several phases of clinical trials. Drug…
Introduction to General Pharmacology General pharmacology covers the fundamental principles of pharmacology, including Drug discovery and development, Souces of Drugs, Dosage forms, Routes of drug administration, Pharmacokinetics, Clinical Pharmacokinetics, Pharmacodynamics, Drug interactions and Adverse drug reactions (ADRs). Understanding these principles is crucial for healthcare professionals, researchers, and students to act safely and effectively using medications. Drug Discovery and Development https://pharmacology.ijcrpp.com/drug-discovery-and-development/ Drug…
Oral drug absorption is a critical process that determines the efficacy and safety of a medication. The bioavailability of a drug depends on various factors, including physical properties, dosage forms, physiological factors, pharmacogenetic factors, and disease states. This article discusses these factors in detail to understand how they affect the absorption and bioavailability of orally…
Understanding the action of drugs on the autonomic nervous system (ANS) can be simplified by drawing a comparison with the adrenaline/epinephrine-induced fight, flight, and fright response. This response, also known as the acute stress response, is the body’s physiological reaction to perceived harmful events, attacks, or threats to survival. To better comprehend the role of…
Mood Stabilizers: Effective Treatment for Mania and Bipolar Disorder Mood stabilizers are a class of drugs used to treat bipolar disorder, a mental health condition characterised by episodes of mania (elevated, irritable mood), depression, and sometimes psychosis. These medications work by balancing the levels of certain neurotransmitters in the brain, particularly dopamine, serotonin, and norepinephrine….
Immunomodulators are drugs that can either suppress or enhance the activity of the immune system. These are two types: Immunosuppressants Immunostimulants Immunosuppressants Immunosuppressants are substances that suppress or inhibit the immune system’s activity. They are often used in medical treatments to prevent the rejection of transplanted organs or to treat autoimmune disorders where the immune…
Central nervous system (CNS) infections are medical conditions caused by various pathogens, such as bacteria, viruses, fungi, or parasites, that affect the brain, spinal cord, or other tissues within the CNS. Below are some common CNS infections, their causes, treatment options, and references for further information. Bacterial meningitis [1]: Cause: Bacteria such as Streptococcus pneumoniae,…
Mycobacterium tuberculosis, also known as Koch’s bacillus, is a species of pathogenic bacteria that is the causative agent of tuberculosis. It was first discovered in 1882 by Robert Koch1. The bacterium has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram…
Asthma Bronchial asthma is a condition characterized by bronchial hyperreactivity and inflammation. The activation of IgE bound to mast cells by the antigen leads to the degranulation of mast cells, resulting in the release of various mediators, such as leukotrienes, prostaglandins, platelet-activating factor, histamine, and protease enzymes. These mediators can cause bronchoconstriction and inflammation, leading…
Dementia and Treatment of Alzheimer’s Disease Alzheimer’s disease is a brain disorder that progressively worsens over time. It’s characterized by changes in the brain that lead to deposits of certain proteins. Alzheimer’s disease causes the brain to shrink and brain cells to eventually die. It is the most common cause of dementia—a gradual decline in…