Understanding the action of drugs on the autonomic nervous system (ANS) can be simplified by drawing a comparison with the adrenaline/epinephrine-induced fight, flight, and fright response. This response, also known as the acute stress response, is the body’s physiological reaction to perceived harmful events, attacks, or threats to survival. To better comprehend the role of…
Oral drug absorption is a critical process that determines the efficacy and safety of a medication. The bioavailability of a drug depends on various factors, including physical properties, dosage forms, physiological factors, pharmacogenetic factors, and disease states. This article discusses these factors in detail to understand how they affect the absorption and bioavailability of orally…
Introduction to General Pharmacology General pharmacology covers the fundamental principles of pharmacology, including Drug discovery and development, Souces of Drugs, Dosage forms, Routes of drug administration, Pharmacokinetics, Clinical Pharmacokinetics, Pharmacodynamics, Drug interactions and Adverse drug reactions (ADRs). Understanding these principles is crucial for healthcare professionals, researchers, and students to act safely and effectively using medications. Drug Discovery and Development https://pharmacology.ijcrpp.com/drug-discovery-and-development/ Drug…
Drug discovery and development is an intricate and multifaceted process that encompasses identifying, designing, and testing prospective new drugs. The primary objective is to discover secure and effective treatments for various ailments and conditions. This composition will delve into the various stages of drug design and screening and the several phases of clinical trials. Drug…
Pharmacokinetics, derived from the Greek words ‘pharmakon’ meaning drug, and ‘kinesis’ meaning movement, is the science that elucidates what the body does to a drug following administration. Pharmacokinetics is the study of how drugs move through the body. It includes processes like absorption, distribution, metabolism, and excretion (ADME), which determine how much of the drug…
Pharmacodynamics is a branch of pharmacology that focuses on the study of how drugs interact with the body at the molecular, cellular, and systemic levels to produce their effects. It involves understanding the mechanisms of drug action (MOA), including drug-receptor interactions, signal transduction pathways, and the pharmacological effects of drugs. “What drug does to the…
Introduction Drugs can interact in various ways, leading to changes in the way they work and potential side effects. Understanding these interactions is essential to ensure the safe and effective use of medications. In this page, we’ll explore pharmacokinetic and pharmacodynamic interactions, additive, synergistic, and antagonistic effects, as well as drug-food and drug-disease interactions. Pharmacokinetic…
Summary Points on Antipsychotic Drugs: Classification of Antipsychotics: Typical (D2 blockers) and Atypical (acting via other mechanisms) Actions of Typical Antipsychotics: Actions of Atypical Antipsychotics: Individual Drugs: Adverse Effects: Other Uses: Key Points: Disclaimer: This article is for informational purposes only and should not be taken as medical advice. Always consult with a healthcare professional…
Antianxiety Drugs: The Relationship Between GABAergic and Serotonergic Activity and Anxiety A reduction in GABAergic activity or an increase in serotonergic activity can lead to anxiety due to mild CNS stimulation. Drugs commonly used to treat anxiety include CNS depressants like benzodiazepines or those that decrease serotonin levels, like buspirone. Benzodiazepines for Anxiety Benzodiazepines are…
Brief Summary Drugs can increase monoaminergic transmission by inhibiting the metabolism or reuptake of neurotransmitters such as serotonin (5-HT) and noradrenaline (NA). MAO Inhibitors MAO-A and MAO-B are enzymes involved in the metabolism of monoamines. Non-selective MAO inhibitors (Tranylcypromine, Isocarboxazid, Phenelzine) irreversibly inhibit both MAO-A and MAO-B. These drugs exhibit many drug and food interactions,…