Parasympathomimetics: Pharmacology and Clinical Applications

Introduction/Overview Parasympathomimetic agents, also referred to as cholinergic agonists, are pharmacologic compounds that mimic the actions of acetylcholine (ACh) within the autonomic nervous system (ANS). Their ability to selectively activate muscarinic or nicotinic receptors underlies a broad spectrum of therapeutic applications, ranging from ophthalmology to urology, and from anesthesia to emergency medicine. An in-depth understanding…

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Pharmacodynamics: Dose-Response Relationships, Potency, Efficacy, and Therapeutic Index

Introduction Pharmacodynamics refers to the study of the biochemical and physiological effects of drugs on the body, and the mechanisms by which these effects are produced. Historically, the term emerged in the late 19th and early 20th centuries as researchers sought to quantify how drugs interacted with biological systems. Early investigations by scientists such as…

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